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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK2
All Species:
14.24
Human Site:
S486
Identified Species:
28.48
UniProt:
Q9H0K1
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0K1
NP_056006.1
926
103915
S486
G
Q
R
R
H
T
L
S
E
V
T
N
Q
L
V
Chimpanzee
Pan troglodytes
XP_508750
883
99166
S443
G
Q
R
R
H
T
L
S
E
V
T
N
Q
L
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546528
993
110460
S561
G
Q
R
R
H
T
L
S
E
V
T
N
Q
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFH6
931
104180
S486
G
Q
R
R
H
T
L
S
E
V
T
N
Q
L
V
Rat
Rattus norvegicus
Q9R1U5
776
84890
D371
Q
P
Q
L
R
N
S
D
L
S
S
L
E
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
L397
E
S
L
R
S
T
L
L
Y
Q
P
P
Q
P
L
Chicken
Gallus gallus
Q9IA88
798
88848
Q394
S
L
L
Y
Q
Q
P
Q
S
L
I
Q
P
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
L660
H
T
Q
Q
Q
H
V
L
Y
Q
Q
E
Q
Q
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
F931
G
P
Y
D
S
L
D
F
A
L
P
S
G
K
G
Honey Bee
Apis mellifera
XP_397175
718
80391
N314
R
T
R
E
S
L
R
N
S
S
Y
D
H
H
A
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
N712
A
Q
Q
Q
Q
Y
M
N
Q
L
T
S
S
T
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
Y108
K
S
G
E
L
F
D
Y
I
V
E
K
G
R
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
N.A.
84.7
N.A.
90.8
43.2
N.A.
45.2
45.4
N.A.
31.5
N.A.
29.6
37.4
23.8
N.A.
Protein Similarity:
100
95.3
N.A.
87.5
N.A.
94.4
56.7
N.A.
58.6
58.9
N.A.
45.2
N.A.
40
49.3
38.1
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
26.6
0
N.A.
6.6
N.A.
6.6
6.6
13.3
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
33.3
13.3
N.A.
33.3
N.A.
20
20
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
17
9
0
0
0
9
0
0
0
% D
% Glu:
9
0
0
17
0
0
0
0
34
0
9
9
9
0
0
% E
% Phe:
0
0
0
0
0
9
0
9
0
0
0
0
0
0
0
% F
% Gly:
42
0
9
0
0
0
0
0
0
0
0
0
17
0
9
% G
% His:
9
0
0
0
34
9
0
0
0
0
0
0
9
9
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
9
% I
% Lys:
9
0
0
0
0
0
0
0
0
0
0
9
0
9
0
% K
% Leu:
0
9
17
9
9
17
42
17
9
25
0
9
0
34
25
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
0
0
9
0
17
0
0
0
34
0
0
0
% N
% Pro:
0
17
0
0
0
0
9
0
0
0
17
9
9
9
9
% P
% Gln:
9
42
25
17
25
9
0
9
9
17
9
9
50
9
0
% Q
% Arg:
9
0
42
42
9
0
9
0
0
0
0
0
0
9
0
% R
% Ser:
9
17
0
0
25
0
9
34
17
17
9
17
9
9
0
% S
% Thr:
0
17
0
0
0
42
0
0
0
0
42
0
0
9
0
% T
% Val:
0
0
0
0
0
0
9
0
0
42
0
0
0
9
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
9
0
9
0
9
17
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _